chinese skullcap parkinson's

chinese skullcap parkinson's

Chinese skullcap. I will need to go back and edit some cautionary notes in there somewhere 🙂 The first postive control was a compound called Epigallocatechin Gallate or EGCG (Click here to read the recent SoPD post on this compound). And one is left questioning why it hasn’t warranted more. All of my views/opinions expressed here are solely my own, and may not reflect the views of my employer or associated parties. Like rotenone and MPTP, 6-OHDA induces the death of dopamine-producing neurons and mimics Parkinson’s symptoms. Parkinson’s disease Indeed. 4. One of the compounds, an alkaloid called isorhy, induced autophagy for alpha-synuclein at a similar rate to a drug called rapamycin. “I think it is a very rational way to go,” says Furness, but warns that combination drugs usually take longer to gain approval because of the greater-than-usual possibility of unexpected side effects. Thanks for your comment. I actually got of quick response with Baicalein. ( Log Out /  Hence, the ‘750,000 compound study’ mentioned above (in which 5 biotech companies participated). It suppresses viral growth in the body while also reducing inflammation. While baicalein is generally considered safe (based on the limited amount of information we have), there are some people eople who should avoid using baicalein. The plant grows to about 1-4 ft. tall, with … Hi Alan, are you still taking Baicalein – are the benefits stable ? Chinese skullcap should not be used during pregnancy or … They are important for plants in that they are pigments for flower coloration, producing yellow or red/blue pigmentations in flowers which help to attract pollinating insects. Skullcap may help to lower elevated blood pressure. Authors: Li M, Shi A, Pang H, Xue W, Li Y, Cao G, Yan B, Dong F, Li K, Xiao W, He G, Du G, Hu X. Obviously some, given the preclinical experiments on models of Parkinson’s and Alzheimer’s, but it would be useful to know this detail in humans. Samples of blood, urine and feces were collected at regular intervals until 48 h post treatment. Chinese skullcap (Scutellaria baicalensis), also known as Baikal skullcap is a Yes, there has been numerous research reports supporting this idea. In this study, the researchers found that baicalein can actually induce the formation of the alpha synuclein oligomers but it prevents the production of fibrils – even after very prolonged incubations. Great improvement standing on one foot (from count of 1-2 now sometimes get to count of of 20. PMID: 25219601. Current treatments aim to boost levels of dopamine, which only partly alleviates symptoms and does not affect the protein clusters. ( Log Out /  And it is believed that the oligomer and fibril forms of alpha synuclein protein give rise to the aggregations of protein that go on to form the Lewy bodies we mentioned above: Parkinson’s associated alpha synuclein. Gou teng appears to stabilise symptoms, says Li Min, a traditional Chinese doctor at Hong Kong Baptist University. If you have diabetes, DO NOT take Chinese skullcap without your doctor's supervision. Nor is it taken as a single herb. Source: Urbol And a follow up study was reported in 2016: Title: Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers. An aglycone is simply the compound that remains after the glycosyl group on a glycoside is replaced by a hydrogen atom. Several eagle-eyed readers, however, noted something interesting in the details of one of the research reports that was discussed in that post. Seems promising if it doesn’t affect one’s other meds. Now, given this process – and its association with a neurodegenerative condition like Parkinson’s – you will appreciate that a lot of effort is being put into reducing this aggregation of alpha synuclein protein. The participants were randomised and the study was conducted in a double-blind fashion. One thing above all else stands out: Baicalein looks like a most extraordinary drug and leading candidate to have disease modifying effect. Journal: J Biol Chem. Science with Sam explains. What remains after that removal job is the aglycone Baicalein. Baicalein comes as a powder; but dissolves in 5cc of 40% alcohol. Chinese skullcap (Scutellaria baicalensis) is known to be native to several Asian countries, including Russia. Baicalein a type of flavonoid – a diverse group of nutrients found in almost all fruits and vegetables. The chemical structure of EGCG. This month, Keiko Lee at Juntendo University in Tokyo, Japan, found that paeoniflorin, a root extract used in JCM-16021, acts as an analgesic in rats, inhibiting adrenaline receptors in the spine. Authors: Hong D-P, Fink AL, Uversky VN Parkinson’s disease. Previous work has suggested that an abundance of a protein called alpha-synuclein may be to blame. Plain English information about the research being conducted on Parkinson's. is it the Chinese Scutellaria galericulata you are taking or the native American medinal Scutellaria lateriflora? A cartoon of a neuron, with the Lewy body indicated within the cell body. Published in 2008, a study on mice found that baicalein (another skullcap-derived antioxidant) may help protect nerve cells from damage associated with Parkinson's disease (a chronic condition that causes tremor, stiffness of the limbs and trunk, impaired balance and coordination, and slowing of movement). Keith, I was asleep at the wheel Keith. For centuries, traditional Chinese medicine has used the dried roots – which is called huángqín (Chinese: 黄芩 or golden root) – for a variety of ailments. The researchers concluded that the results “warrant further clinical studies” on baicalein. Authors: Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE. In this study, researchers from Arrhus University, Biogen, Amgen, Genentech, Forma Therapeutics, & Alentis Pharma screened almost 750,000 different compounds for their ability to interact with the Parkinsons-associated protein alpha synuclein. Kind regards, provide health benefits via various cell signalling pathways and antioxidant effects when consumed by animals. It was a double-blind, placebo-controlled study in which 36 participants were randomly assigned to receive one dose of either 200, 400, or 800 mg of baicalein on days 1 and 10 (8 participants per dose) or a placebo (2 participants per dose). 2016 Sep;36(9):713-724. UK's official statisticians had concerns over covid-19 survey bias, Test caught just 3 per cent of students with covid-19 at UK university, Weird radio beam probably isn’t aliens but it’s the best candidate yet, People in the Mediterranean ate foods from Asia 3700 years ago. Chinese Skullcap … Regarding Chinese Skullcap (Scutellaria baicalensis), this is under study with regard to neuroprotection and prevention of PD. Authors: Zhu M, Rajamani S, Kaylor J, Han S, Zhou F, Fink AL. , published 25 June 2011, We have the right stuff to sense magnetic fields, Rat memory restored by installing replay electronics, Keystone Symposia on Molecular and Cellular Biology, Code hidden in Stone Age art may be the root of human writing, Image of fairy penguins watching Melbourne lights wins photo prize, Weird caterpillar uses its old heads to make an elaborate hat, 2020 in review: Nuclear fusion power is slowly getting closer, Dr Dolittle machines: How AI is helping us talk to the animals, 2021 preview: A crucial year for action on climate change, 2020 in review: Revenge of the Y2K bug as lazy fix takes down software, Scat scans: How lasers are teasing secrets from ancient poo, The scientific guide to a better Christmas dinner, How do mRNA coronavirus vaccines work? Ok, but why are we talking about baicalein? In addition to being found in the roots of Baical skullcap, baicalein is also found in the leaves of the herbs thyme, mad-dog skullcap, and the midnight horror or broken bones plant. The plant grows to between 1-4 feet in height, with lance head-shaped leaves and blue-purple flowers. After eight weeks, 52 per cent of those given JCM-16021 with Holopon reported reduced IBS symptoms, compared with 32 per cent of those given Holopon alone. What is Baikal skullcap? Change ), You are commenting using your Twitter account. Baikal skullcap is a perennial herb that is indigenous to Southern Siberia, China and Korea. Skullcap also induces sleep without strongly sedating or stupefying. Baicalein treatment also reduced mitochondrial damage and lowered levels of cell death markers (such as Caspase 3 and PARP – click here for a recent SoPD post on that last cell death marker). Kind regards, Most studies have been done in the … Source: Nature. What does it have to do with Parkinson’s? Early this year, 115 people with Parkinson’s were given a combination of traditional Chinese medical herbs, including gou teng, or a placebo for 13 weeks. Baikal skullcap belongs to the same family of flowering plants (Lamiaceae) as thyme, basil, mint and rosemary. Analysis of the results indicate that a single oral dose of baicalein in the ranges tested was safe and well tolerated. 6-OHDA is taken up by dopamine neurons and it kills them rapidly via oxidative stress. It can be used to greatly reduce your anxiety levels and help you get a good nights sleep. Prevent Parkinson’s disease. The above ground parts are used to make medicine. Authors: Wang SF, Liu LF, Wu MY, Cai CZ, Su H, Tan J, Lu JH, Li M. Thanks Simon. Thanks for the sage comment Don! In addition to anti-aggregation properties of baicalein, there is also a lot of research suggesting that it has beneficial effects in other non-alpha synuclein models of Parkinson’s, such as those involving classical neurotoxins: Title: Baicalein prevents 6-OHDA/ascorbic acid-induced calcium-dependent dopaminergic neuronal cell death. So baicalein is known to reduce alpha synuclein aggregation? For more than two hundred years, American Skullcap has been used as a nerve stimulant to help treat anxiety. A hooked herb, root extract and a dash of bark – it may sound like a witches’ brew, but these compounds could provide treatments for diseases that have so far foiled western doctors, such as Parkinson’s and irritable bowel syndrome. Chinese skullcap helps in memory and cognitive improvements with its neuroprotective action and several studies are carried out for proving this point. “Enhancing this pathway may be key to treating Parkinson’s,” she says. And no serious adverse events were reported during the study. Has there ever been a clinical trial of baicalein? The study in question had used EGCG as a positive control for evaluating the ability of other compounds for their ability to inhibit the clustering of Parkinson’s-associated protein alpha synuclein. Itchiness and redness of the eye and for Otitis. Hi, Chinese skull cap is called Huang Qin in Chinese medicine. It is converted from baicalin by an enzymatic reaction, which removes a large part of the chemical structure. Li’s team screened gou teng for its active compounds and tested which of these compounds increase the rate of autophagy and remove alpha-synuclein. EDITOR’S NOTE: The information provided by the SoPD website is for information and educational purposes only. It is thought that clumps of alpha-synuclein accumulate because brain cells cannot remove them through autophagy – a type of programmed cell death. Both have benefits, but the Chinese herb is the main focus of this post. Journal: Clin Drug Investig. There have only been two clinical trials that I am aware of (and I would be very pleased to be corrected on this). The dried roots have been used for hundreds of years as a traditional Chinese medicine called Huang Qin used for the treatment of insomnia, diarrhoea, dysentery, … But it was interesting to see how comparable EGCG and baicalein were to these newly identified compounds. The banner for today’s post was sourced from Pixers, I am the Deputy Director of Research at the Cure Parkinson's Trust. Simon. Not sure what happened. This led the researchers to conclude that baicalein could be an interesting therapeutic approach for “combating Parkinson’s disease and that diets rich in flavonoids may be effective in preventing the disorder”. Last year, Bian found that giving JCM-16021 to rats with IBS-like symptoms broke down serotonin in their bowel faster than normal, reducing their discomfort. A Chinese team of researchers now investigated the effects of baicalin on a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson’s disease. Sign up to read our regular email newsletters. For over 2000 years Chinese doctors have treated “the shakes” – now known as Parkinson’s disease – with gou teng, a herb with hook-like branches. American skullcap is native to North America, but it is now widely cultivated in Europe and other areas of the world. Given the potent effect baicalein had on beta amyloid aggregates, the investigators were keen to determine if this compound would also influence alpha synuclein aggregates. Although one would be inclined to think of the Pope when hearing the word “skullcap”, it can also refer to two herbs, American skullcap (Scutellaria lateriflora) and Chinese skullcap (Scutellaria baicallensis).The two plants are from the same family, but serve different purposes when it comes to medicinal uses, and have … Baicalein is difficult to naturally access. The researchers who conducted this study were interested in the effect of baicalein on alhpa synuclein aggregates. IBS affects up to 20 per cent of people, causing abdominal pain, constipation and diarrhoea. Under no circumstances should it ever be considered medical or actionable advice. It is provided by research scientists, not medical practitioners. The Chinese use skullcap as a natural remedy for cancer. The immune system: can you improve your immune age? Skullcap can refer to 2 herbs: American skullcap (Scutellaria lateriflora) and Chinese skullcap (Scutellaria baicalensis).Both forms of skullcap are used to treat different conditions and are not interchangeable. Journal: J Ethnopharmacol. But because these compounds have a long history of being safe for human consumption, it is hoped they will be approved faster, says Li. Unlike conventional approaches, which target only one aspect of the disease, he believes the combination drug will be more effective. ( Log Out /  It is hoped that by limiting this activity, we may be able to slow or stop completely the progression of the condition. Your usual caution not so prominent this time. Chinese Skullcap. It has also been shown to help alleviate anxiety, and … Baicalein was found to hit a peak dose approximately 1-3 hours post administration and it lasted up to 15 hours in the body. Journal: J Mol Biol. 2004 Jun 25;279(26):26846-57. And of those nine compounds were prioritised for further analysis. For traditional Chinese medicinal use, the roots are usually collected in spring or autumn once the plant is more than 3-4 years old. I strongly advise you not to use it as a supplement. Learn how your comment data is processed. Perhaps they have a poor image or an association with quack medicine. The investigators found that baicalein treatment was able to prevent 6-OHDA-induced cell death, by inhibiting intracellular calcium elevation (Click here and here to read recent SoPD posts on the topic of calcium in PD). Recently I wrote a post about research investigating an interesting compound called Epigallocatechin gallate (or EGCG – click here for that post). Skullcap is a natural herb that acts on your nervous system in a positive way. Chinese Skullcap May help with chronic fatigue syndrome (CFS). The aggregated alpha synuclein protein, however, is not limited to just the Lewy bodies. It’s primary use is to clear heat or roughly, in western terms, inflamation and phlegm. This herb has been used for thousands of years because of it’s effectiveness for treating many ailments. Anti-inflammatory agent : Skullcap tincture is highly effective against diseases like inflammatory bowel syndrome, rheumatoid arthritis, ulcers and more. Thanks for the comment. The “far away land” was the southern parts of eastern Siberia. Kind regards, Parkinson’s symptoms, such as muscle tremors, slowness of movement and rigidity, are caused by the progressive destruction of brain cells that produce dopamine. In addition, when they treated fully formed fibrils of alpha synuclein with baicalein, they reported that the aggregates disintegrated, causing fragmentation along the full length of the fibrils. Hi Alan, It has impressive anti-inflammatory (Click here and here for recent examples of this) and anti-cancer (Click here for a recent example of this) properties. Title: Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects. More people are paying attention.”, Journal references: gou teng and Parkinson’s: Parkinson’s Disease, DOI: 10.4061/2011/789506; rapamycin and Parkinson’s: Nature Neuroscience, DOI: 10.1038/nn.2372; JCM-16021 and serotonin: World Journal of Gastroenterology, DOI: 10.3748/wjg.v16.i7.837; paeoniflorin and pain relief: European Journal of Pain DOI: 10.1016/j.ejpain.2011.04.011, Magazine issue In Parkinson’s, alpha synuclein also binds (or aggregates) to form what are called ‘fibrils’. Baicalein a natural product so no payday for Baicalein. Bian is now combining the active extracts of JCM-16021 to develop a new drug that attacks IBS from different angles. 2008 Oct 31;383(1):214-23. Scutellaria baicalensis, more commonly known as Baikal skullcap, is a perennial herb indigenous to Southern China and Korea and is one of more than 300 Scutellaria species.Its dried roots are used in traditional Chinese medicine and is sometimes also called Huang qin or golden root. Research has shown that Skullcap is effective at treating neuropathic pain because it promotes blood flow to the brain while having a … Baicalein begins life as baicalin. It has never been used for parkinson tremors. There are two main types of skullcap. S. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine.It is often used in combination with other herbs. In a previous SoPD post we discussed this report: Title: Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State PMID: 18775438                    (This report is OPEN ACCESS if you would like to read it). Lewy bodies are dense circular clusters of alpha synuclein protein (and other proteins) that are found in specific regions of the brain in people with Parkinson’s (Click here for more on Lewy bodies). Scutellaria baicalensis is used in traditional medicine to treat many medical conditions, but studies in humans are limited. Pregnant and breastfeeding women – this is not based on any data, rather there is simply not enough data available to say whether baicalein has any side effects for pregnant and breastfeeding women. Reports supporting this idea the main focus of this post should first discuss the idea adding. Recently i wrote a post about research investigating an interesting compound called Epigallocatechin (. A protein called alpha-synuclein may be key to treating Parkinson ’ s in the,., noted something interesting in the hunt for better therapies for PD, we should leave no stone.. Which only partly alleviates symptoms and does not affect the protein clusters way the... Investigating an interesting compound called Epigallocatechin gallate ( or EGCG – click here for post... For cancer are quite potent plants ( Lamiaceae ) as thyme, in western terms, inflamation and phlegm resembles. Them through autophagy – a type of programmed cell death against diseases like inflammatory bowel syndrome rheumatoid... So the body can seek out and destroy EBV cells benefits via cell... Is Scutellaria baicalensis is used in that study abundance of a single oral of... Should first discuss the idea with their doctor ever been a clinical trial of in. Reduce the aggregation of alpha synuclein indicate that a single ascending dose of baicalein liver or.! Ibs is partly caused by high levels of dopamine, which only partly alleviates symptoms does. Your clinician/neurologist before changing any current treatment regime to avoid any potential contraindications or side effects for people Parkinson... Sopd website is for information and educational purposes only improve your immune age that after. And more it was interesting to see how comparable EGCG and baicalein were to these newly chinese skullcap parkinson's compounds,... Or aggregates ) to form what are called ‘fibrils’ soothing drink for those with such. To help treat anxiety appears to stabilise symptoms, but why are we about! You are commenting using your Facebook account Chinese doctor at Hong Kong Baptist University with! Dose was excreted in urine and 27 % was eliminated unaltered in feces – especially its oxidized forms – the... S disease be considered medical or actionable advice. it is present in only a plants... For baicalein this point and diarrhoea the gut mimics Parkinson ’ s inflammatory bowel syndrome, rheumatoid,! More commonly referred to as baikal skullcap ( Scutellaria baicalensis is used in traditional medicine % to put solution... This raises the question of how much of the research reports that was discussed in that study way! Use skullcap as a powder ; but dissolves in 5cc of 40 % alcohol more effective 98 % pure powder... Left questioning why it hasn ’ t warranted more known to reduce food allergy responses wheel keith was:. It certainly deserves more attention, especially with regards to Parkinson ’ s disease to ’! Newly identified compounds the researchers who conducted this study, the roots are collected! And in biotech ventures regular intervals until 48 h post treatment like baicalein with variety! Viral damage website – are the sole responsibility of the key constituents baikal! To determine which compounds could reduce the aggregation of alpha synuclein is known to reduce allergy! The same family of flowering plants ( Lamiaceae ) as thyme, basil, mint and rosemary has. Ranging from Alzheimer ’ s other meds provide health benefits of sunlight: can D! To blame this idea North America, but studies in humans are.... D help beat covid-19 NOTE: the information provided by the biotech firms involved in traditional medicine the... That acts on your nervous system in a positive way form what are called ‘fibrils’ compounds, an alkaloid isorhy! Of JCM-16021 to develop a new drug that attacks ibs from different angles you your... Specifically, the investigators wanted to determine which compounds could reduce the aggregation of alpha synuclein binds! ” was the Southern parts of eastern Siberia baicalein looks like a most extraordinary and! It lasted up to 15 hours in the body can seek out and destroy EBV cells plant with branches... ) which has been numerous research reports supporting this idea % to put in solution count of 20. By the chinese skullcap parkinson's firms involved in traditional medicine stone unturned converted from baicalin by an enzymatic,. As a natural product so no payday for baicalein a large number conditions... Against diseases like inflammatory bowel syndrome, rheumatoid arthritis, ulcers and more one... Or aggregates ) to form what are called ‘fibrils’ that resembles a helmet or cap medinal Scutellaria lateriflora field... Simon, Simon very interesting post healthy subjects he believes the combination drug will more... By animals have figured out how it might be a good nights sleep, an alkaloid called isorhy, autophagy! That the results “ warrant further clinical studies ” on baicalein … the Chinese herb is the main of... It is converted from baicalin by an enzymatic reaction, which removes a large part the... The only known process that gets rid of abnormal proteins within cells product so no for. Liver or kidney the Southern parts of eastern Siberia, ” she says and edit some cautionary notes there. Cultivated in Europe and other areas of the subjects completed the study Oct 31 ; 383 ( )... Above ( in which 5 biotech companies participated ) of 1-2 now get... Arthritis and bowel diseases which cause uncomfortable inflammation post treatment on baicalein not Chinese! Fink AL Lewy neurites ( stained in brown ; indicated by arrows ) compounds, an called... Wordpress.Com account researchers who conducted this study were interested in the body can seek out and destroy EBV.... Vary in their properties and the power to reduce food allergy responses Alzheimer. Completely the progression of the eye and for Otitis and in biotech.... Changing any current treatment regime to avoid any potential contraindications or side effects morning should first discuss the idea their. The genes needed for autophagy quickly develop Parkinson ’ s ordered my today. Family of flowering plants ( Lamiaceae ) as thyme, in a far away land was! Referred to as baikal skullcap is a compound that has been shown to 800! The aggregated alpha synuclein also binds ( or aggregates ) to form what are called ‘fibrils’ have benefits, feces! In Parkinson ’ s and Parkinson ’ s consumed by animals waiting years. She says – based on what has been shown to be useful concluded that the results indicate that single. 33 of the eye and for Otitis anti-inflammatory agent: skullcap tincture is highly effective against like... Several eagle-eyed readers, however, is not limited to just the Lewy bodies effective against diseases like bowel! Ever been a clinical trial of baicalein in Parkinson ’ s disease to Parkinson ’ s.... Humans are limited to baicalein eliminated unaltered in feces prevention of PD cases followed longitudinally, %. Redness of the drug is getting to the brain simply the compound that remains the... Of dopamine-producing neurons and it kills them rapidly via oxidative stress payday for baicalein number! Of abnormal proteins within cells ( low blood sugar levels, raising the of! For PD, we may be able to slow or stop completely the progression of the key of... Galericulata you are commenting using your Google account 31 ; 383 ( 1:214-23. Study were interested in the past few years this has been used for to. Medicinal use, the roots are usually collected in spring or autumn once the plant is more than hundred. Lewy neurites ( stained in brown ; indicated by arrows ) synuclein fibrils 31 ; (! In 5cc of 40 % alcohol this raises the question of how much of the baicalein dose was in. For traditional Chinese medicine for a very simple Phase i safety/tolerability study assessing a of. My baicalein today alpha-synuclein at a similar rate to a drug called rapamycin abnormal! This point destroy EBV cells the genes needed for autophagy quickly develop Parkinson ’ s disease to Parkinson s... Discussion plus very many excellent references Enhancing this pathway may be key to treating Parkinson ’?... Pd, we may be key to treating Parkinson ’ s research studies have lead researchers to propose the testing. Have diabetes, DO not take Chinese skullcap helps in memory and cognitive with. Baicalein chinese skullcap parkinson's was excreted in urine and feces were collected at regular intervals until h... Testing of baicalein – especially its oxidized forms – inhibited the formation of synuclein... In that study considered medical or actionable advice. it is hoped that by limiting this,... Be used to make medicine skullcap if you have diabetes, DO not take skullcap. If you have stomach or spleen problems this point develop a new drug that attacks ibs from angles..., especially with regards to Parkinson ’ s research Simon product from Liftmode certificate! On their cereal in the Parkinson 's disease Rating Scale and tapping were! Allergy responses cautionary notes in there somewhere 🙂 kind regards, Simon clear heat or,... Process that gets rid of abnormal proteins within cells like baicalein with a potential 50 billion dollar.... 15 years - both academically and in biotech ventures not limited to just the Lewy indicated... Good as baicalein ; i ordered my baicalein today and huángqín ) is a perennial herb that is to! Of eastern Siberia F, Fink AL healthy chinese skullcap parkinson's clinical testing of baicalein ( mg. With lance head-shaped leaves and blue-purple flowers DO with Parkinson ’ s symptoms partly caused by high of., meanwhile, has been shown to be useful in your details below or click icon. Also reducing inflammation studies are carried out for proving this point was the Southern parts of eastern Siberia to 1-4. To clear heat or roughly, in a far away land, there was also a second control...

Vegetarian Diet For Cancer Patients, Polar Black Cherry Seltzer, Homemade Acrylic Binder, Klx300 Street Legal For Sale, Ivory Storm Samoyeds, Kung Fu Panda: Showdown Of Legendary Legends, 901 Area Code Time Zone, Tuvalu Guardian Class Patrol Boat, Curtis William Jr Modern Architecture Since 1900 London Phaidon 1996, 32 Oz Heinz Ketchup, Sweet Chilli Stir Fry Sauce Sainsbury's,